|
KMID : 0375319930150020293
|
|
Journal of Clinical Pathology and Quality Control
1993 Volume.15 No. 2 p.293 ~ p.298
|
|
|
Diagnostic Significance of lactate Dehydrogenase and Its Isoenzyme in Cerebrospinal Fluid of Patients with Various Neurological Disorders
|
|
김도형
이도훈/황유성/김진규
|
|
|
Abstract
|
|
|
Lactate dehydrogenase (LD) is a fermentative enzyme present in most tissues and in all body fluids examined. This enzyme levels are increased in cerebrospinal fluid (CSF) and serum in various pathological conditions. The aim of the present study
was to
investigate the meaning of LD changes in CSF in patients with various neurological disorders.
CSF specimens form 10 patients were analyzed for total LD activity and LD isoenzyme distribution. We examined total LD activities of CSF suing Hitachi automatic blood chemistry analyzer 736-40. The LD isoenzymes were measured with use of the
Helena
LD
Isoenzyme Electrophosis Procedure.
The total LD activities were elevated in the CSF of patients with bacterial meningitis, meningitis due to neurocysticercosis, arachnoid cyst, hydrocephalus, thalamic intracerebral hemorrhage, seizure, tuberculous meningitis. The electrophoretic
pattern
of CSF LD isoenzyme were useful ratio indicates the presence of the disease in the central nervous system.
We concluded that determination of CSF total LD & LD isoenzyme distribution can be helpful for assessing neurological disorders.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|